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The persistence of hyperglycemia in diabetes triggers a sequence of local metabolic, vascular, and neurochemical modifications, which ultimately culminate in vascular disease and microangiopathy [25]

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Apply morning and evening to the under-eye area and eyelids, gently patting it in with circular motions to stimulate microcirculation

doi: 10.1038/nrneurol.2017.165 3 GoetzCG

Specific genetic polymorphisms and variations in genes related to collagen production, inflammation, and wound healing have been implicated in the disease